March Madness 2026: Picking every West region 1st-round game, including heavily favored Arizona
Tommy Lloyd is a phenomenal 144-35 in five seasons as Arizona’s head coach, but there’s another stat you’ll hear a lot over this NCAA tournament.
Lloyd has yet to take Arizona beyond the Sweet 16 in the tournament. This should be the season Arizona gets beyond that point. They have a team that was an obvious No. 1 seed and is on a very short list of favorites to win it all. And the Wildcats woke up Monday as the biggest favorite in any first-round game.
Here are the first-round picks for the West region with all odds from BetMGM (No. 6 seed BYU isn’t listed; the Cougars will play the winner of the First Four game between Texas and NC State):

No. 12 High Point (+9.5) over No. 5 Wisconsin
For years, the moment the odds for the first round of the NCAA tournament came out, bettors would search for the Wisconsin game and take the under. Those days are done. This is a different Wisconsin era, with a team that wants to shoot 3s more than play defense. And High Point can score, with an up-tempo attack that averaged 90 per game. You’d have never taken over 164.5 on a Wisconsin game for decades, but for this one it seems low. High Point can score enough to give Wisconsin a scare.
No. 13 Hawaii (+15.5) over No. 4 Arkansas
Hawaii plays a truly unique no-help defense, and it works. They are 43rd in college basketball in defensive efficiency via KenPom.com and the best in opponents’ assists per basket. Basically, the Rainbow Warriors will not allow any assisted baskets as they play one-on-one defense and never come off their man to help. Not helping at all on Arkansas superstar freshman Darius Acuff Jr. might lead to Acuff going for 50 points, but we’ll see. It’s a strange prep for Arkansas, and it could keep the game within the number.
No. 3 Gonzaga (-18.5) over No. 14 Kennesaw State
Gonzaga is good and of all the matchups Kennesaw State could get, this isn’t a great one. Kennesaw lives off of offensive rebounds and getting to the free-throw line. The Bulldogs limit offensive rebounds and don’t foul much. Gonzaga should roll to an easy win.
No. 2 Purdue (-25.5) over No. 15 Queens
This line opened at -22.5 or -23.5 and moved toward the favorite. As we’ve seen with other matchups with the top teams, early bettors clearly believe it will be a very chalky tournament again. Purdue has the most efficient offense in college basketball and Queens is 322nd in defense, via KenPom. This could get ugly.
No. 10 Missouri (+2.5) over No. 7 Miami
Sometimes the selection committee makes an avoidable mistake in bracketing. There’s no way that Missouri, as a No. 10 seed, should get the benefit of playing what will amount to a first-round home game in St. Louis. That’s unfair to Miami, which played well in Jai Lucas’ first season as head coach. Miami is probably the slightly better team but we’ll go with the pseudo home-court advantage.
No. 1 Arizona (-31.5) over No. 16 LIU
There were two spreads with No. 1 seeds posted early in the week (the First Four determines the other two No. 1 seed matchups), and both moved at least two points toward the favorites. Think everyone was noticing the trend of the top seeds being more dominant over the past couple tournaments? Like Duke’s line moving three points, this one moved from its opener of -29.5. Arizona is a very good team, and while 31.5 points is a lot, let’s just buy into the chalk trend.
No. 9 Utah State (-1.5) over No. 8 Villanova
This is a fun 8-9 matchup. Neither team is that bad. Usually you’d go with the Big East team over the Mountain West team, but the Big East wasn’t great this season and Villanova went 0-4 against its top teams, UConn and St. John’s. Utah State is well rounded with an efficient offense, and the Aggies get the nod.