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Blue Jays lose 2 All-Star players mid-game Sunday

The Toronto Blue Jays suffered a brutal sequence of events during Sunday’s matchup against the Pittsburgh Pirates, losing two of their most important players in the same inning. Pitcher Dylan Cease and first baseman Vladimir Guerrero Jr. both exited the game during the fifth inning, creating another injury concern for a team that has already been heavily impacted by health issues throughout the MLB season.

While initial reports suggest neither injury appears severe, the sight of two All-Star-caliber players leaving in the middle of a game was the last thing Toronto needed.

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Apr 3, 2026; Chicago, Illinois, USA. Toronto Blue Jays starting pitcher Dylan Cease (84) delivers a pitch against the Chicago White Sox during the first inning at Rate Field. Mandatory Credit: Kamil Krzaczynski-Imagn Images

Fifth Inning Turns Into a Nightmare for Toronto

The Blue Jays difficult afternoon began in the top half of the fifth inning. Cease was forced to leave the game after appearing to suffer a leg injury. Shortly after his departure, Toronto announced that the right-hander exited due to left hamstring discomfort. Things only got worse in the bottom half of the inning.

Guerrero was struck by a sinker from Mitch Keller directly on the elbow. The impact immediately raised concern as Guerrero was removed from the game and replaced. Fortunately for Toronto, early testing delivered some positive news. The team later announced Guerrero had suffered a right elbow contusion, and X-rays came back negative for a fracture.

Toronto’s Injury Problems Continue to Grow

Even if Cease and Guerrero avoid lengthy absences, the injuries add to what has already become a difficult season from a health standpoint. The Blue Jays have been among the league’s most injury-riddled teams throughout the year. Currently on the injured list are catcher Alejandro Kirk, outfielder Nathan Lukes, and versatile player Addison Barger.

Toronto has also already lost key contributors for the season. Outfielder Anthony Santander is sidelined after undergoing shoulder surgery, while pitchers Jose Berrios, Bowden Francis, and Cody Ponce are all done for the year. In addition, Shane Bieber has yet to make his season debut, while veteran Max Scherzer also remains unavailable.

Cease’s Durability Has Been One of His Greatest Strengths

One of the most concerning aspects of Cease’s injury is how unusual it is to see him sidelined at all. Since making his major league debut with the White Sox in 2019, Cease has built a reputation as one of baseball’s most durable starting pitchers.

Outside of a brief COVID-related injured list stint in 2021, he has avoided major injury issues throughout his career. Since the shortened 2020 season, Cease has made at least 32 starts every year, consistently taking the ball and giving his team dependable innings.

Because of that track record, any injury involving the right-hander naturally attracts additional attention.

May 4, 2026; St. Petersburg, Florida, USA. Toronto Blue Jays first baseman Vladimir Guerrero Jr. (27) reacts after striking out against the Tampa Bay Rays in the first inning at Tropicana Field. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

Guerrero Has Rarely Missed Time

Guerrero’s injury history is equally impressive. Across eight major league seasons, the Blue Jays star has never landed on the injured list. Durability has been a major part of his value to Toronto, as he has appeared in at least 155 games and surpassed 675 plate appearances in each of the last five seasons.

Players with that type of availability are difficult to replace. Although the initial diagnosis appears encouraging, Toronto will undoubtedly proceed cautiously with one of the most important bats in its lineup.

Blue Jays Hoping for Good News

The immediate outlook appears better than the worst-case scenarios many feared when both players exited Sunday afternoon. Negative X-rays for Guerrero provide relief, and hamstring discomfort does not necessarily indicate a serious issue for Cease.

Still, for a team already dealing with a seemingly endless list of injuries, even short absences would create another challenge. The Blue Jays have already spent much of the season trying to overcome health setbacks. Losing two All-Star players in the same inning served as another reminder of just how quickly things can change during a long baseball season.

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