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Predicting the winner of every MLB game on Wednesday, April 1, 2026

✇Yahoo! Sports - News, Scores, Standings, Rumors, Fantasy Games

Winning in MLB on a daily basis is one of the toughest challenges in sports. With 162 games, constant lineup changes, pitching matchups, and the unpredictable nature of baseball, picking winners isn’t about guessing—it’s about analyzing matchups and picking up on patterns. Every day presents a new slate, new opportunities, and new value. From analyzing starting pitchers and bullpen usage to identifying hot lineups and favorable matchups, success comes from staying consistent and trusting the process over the long haul. Here are today’s MLB predictions for final scores and the winners around the league.


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Twins at Royals

Sep 26, 2025; Philadelphia, Pennsylvania, USA; Minnesota Twins pitcher Joe Ryan (41) throws a pitch during the second inning against the Philadelphia Phillies at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images
  • Pitching Matchup: Ryan vs. Cameron
  • Score Prediction: 5-3
  • Winner: Twins

Rangers at Orioles

  • Pitching Matchup: Rocker vs. Rogers
  • Score Prediction: 6-1
  • Winner:Orioles

White Sox at Marlins 

  • Pitching Matchup: Smith vs. Alcantara
  • Score Prediction:4-3
  • Winner: Marlins

Nationals at Phillies

  • Pitching Matchup: Cavalli vs. Sanchez
  • Score Prediction:6-3
  • Winner: Phillies

Pirates at Reds

MLB's stat leaders prediction for National League
Pittsburgh Pirates starting pitcher Paul Skenes (30) pitches against the Cincinnati Reds in the first inning at Great American Ball Park. Credit: Katie Stratman-Imagn Images
  • Pitching Matchup: Skenes vs. Abbott
  • Score Prediction:3-1
  • Winner: Pirates

Rockies at Blue Jays

  • Pitching Matchup: Freeland vs. Gausman
  • Score Prediction:7-3
  • Winner: Blue Jays

Athletics at Braves

  • Pitching Matchup: Severino vs. Sale
  • Score Prediction: 5-4
  • Winner: Braves

Rays at Brewers

Oct 16, 2025; Los Angeles, California, USA; Milwaukee Brewers pitcher Jacob Misiorowski (32) reacts after striking out Los Angeles Dodgers first baseman Freddie Freeman (5) for the last out of the third inning of game three of the NLCS during the 2025 MLB playoffs at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images
  • Pitching Matchup: Rasmussen vs. Misiorowski
  • Score Prediction:4-2
  • Winner: Brewers

Angels at Cubs

  • Pitching Matchup: Kikuchi vs. Boyd
  • Score Prediction: 6-3
  • Winner: Cubs

Mets at Cardinals 

  • Pitching Matchup: Peralta vs. Liberatore
  • Score Prediction: 5-2
  • Winner: Mets

Yankees at Mariners

Chris Russo Cam Schlittler pronunciation
Oct 2, 2025; Bronx, New York, USA; New York Yankees starting pitcher Cam Schlittler (31) walks in from the bullpen prior to game three of the Wildcard round for the 2025 MLB playoffs against the Boston Red Sox at Yankee Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images
  • Pitching Matchup: Schlittler vs. Kirby
  • Score Prediction: 3-2
  • Winner: Yankees

Red Sox at Astros

  • Pitching Matchup: Crochet vs. Burrows
  • Score Prediction: 5-3
  • Winner: Red Sox

Giants at Padres

  • Pitching Matchup: Houser vs. Pivetta
  • Score Prediction: 3-0
  • Winner: Padres

Guardians at Dodgers

Jun 19, 2025; Los Angeles, California, USA; Los Angeles Dodgers pitcher Yoshinobu Yamamoto (18) delivers a pitch during the first inning against the San Diego Padres at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images
  • Pitching Matchup: Williams vs. Yamamoto
  • Score Prediction: 4-3
  • Winner: Dodgers

Tigers at Diamondbacks

  • Pitching Matchup: Skubal vs. Gallen
  • Score Prediction: 6-2
  • Winner: Tigers
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