Pytho AI wants to compress mission planning from days to mere minutes.

Strong by Form has designed a structural floor piece that can span longer distances than existing engineered wood, making it a replacement for steel or concrete. At the same time, the product is lighter than all three.

MacroCycle's approach to recycling dramatically reduces the amount of energy needed to produce new material, potentially lowering costs to the point where it could compete with virgin plastic.

Mbodi users prompt the software with natural language, and its cluster of AI agents works to make training easier.

Damoa pinpointed the problem: the complex, multi-step process moving a container from a ship to a freight train. He founded Glīd Technologies to try and solve it.

Large enterprises routinely buy more electricity than they use. COI Energy has a patented platform that lets them sell and share.

The company's so-called Pathfinder software can look at almost anything — buildings, tree-lined roads, even aerial views — and quickly match it to a database and generate real-time navigation.

“What we really do is we took the most constrained, complex, and costly medical imaging solution in radiology, and we supplanted it with what is the most accessible, simple and affordable, which is CT,” Sean Walsh, RADiCAIT’s CEO told TechCrunch. 

India-based Miraqules developed a nanotechnology that mimics blood clotting proteins to quickly stop heavy bleeding.

Although Maxim was convinced that gene therapy could reverse PKD, the biggest hurdle was creating a mechanism to deliver the drugs directly to the diseased cells.

These 20 companies are more than just early-stage startups — they’re the architects of what’s next. And they’ll have just six minutes on the Disrupt Stage to prove it.