Can You Be Allergic To Other People? Yes, And It Sounds Like The Worst Thing Ever



Another crazy Mercedes went for crazy money, but not as crazy as that Uhlenhaut Coupe three years ago.

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Look for eight show cars on the stand, from Alex Palau’s Indy 500 winner to a Civic Type R Rally XP, and lots of performance parts.

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Mazda Vision X-Coupe and the Mazda Vision X-Compact, wherein the X is pronounced as “cross.”

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The ruling weakens NASCAR’s legal stance as its antitrust battle with 23XI Racing and Front Row Motorsports heads toward a December trial.
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After spinning Jeb Burton on the cool-down lap and calling him a “dumbass” on live TV, Mayer will sit out the Xfinity finale at Phoenix.
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Ben & Jerry’s co-founder Ben Cohen is remaining defiant and says he will produce the ice cream independently

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From live blues performances in St Louis and kayaking on the Lake of the Ozarks, to driving Route 66 through Pulaski County, Annabel Grossman delves into the best of Missouri

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‘All of a sudden Elijah Wood started to walk down the aisle,’ say newlyweds of the surprise

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The Reform MP added he wanted to crack down on the ‘anxiety generation’

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Conservative leader Kemi Badenoch asked the prime minister on Wednesday whether he stuck by his pledge not to raise income tax, national insurance or VAT
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Hadush Kebatu, who was wrongly freed from prison instead of being sent to an immigration detention centre, was given the money after threatening to disrupt his deportation to Ethiopia

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Samia Suluhu Hassa likely victorious after rival disqualifications led to protests

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From wellness to luxury, sustainability stays to beachside villas, the Island of the Gods has a hotel for every traveller

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The Pentagon took issue with the film’s claims about the reliability of its missile defense system

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Feel your best and ease stress
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One of the world’s oldest herbs, use of cilantro dates back to Ancient Egypt

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The ‘herb of grace’ used in tea and supplements has been used for centuries in India

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Lord Hermer also said that he is ‘extremely concerned’ about the impact the case may have had about the public’s trust in the UK’s national security and criminal justice systems

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I’ve rounded up the best Currys Black Friday deals you can shop right now

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The ancient Mediterranean herb has been cultivated for thousands of years

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Storm has left devastation in its path with 120mph winds

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Scientists believe nutrients in dairy products may support neuronal maintenance

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Donald Trump mimics Narendra Modi as he attempts to take credit for ending May’s India-Pakistan war at APEC summit in South Korea

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A plot to kill Masih Alinejad at her Brooklyn home came ‘chillingly close’, prosecutors allege

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The attraction is set to open at Old Brewer’s Yard in Covent Garden

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Talks continue between Floyd Mayweather and Manny Pacquiao over a rematch of their revenue-spinning 2015 meeting, with major details emerging

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The recently-suspended Eastern Airways recorded the highest cancellation rate at 12.2 per cent

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Donald Trump said the U.S. has “pretty much finalised” the details of a fraught trade deal with South Korea as he marked the last pitstop on his whirlwind Asia tour Wednesday.

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A butterfly with a broken wing is able to fly again after undergoing a successful wing transplant.

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The Israeli Defense Forces (IDF) has published drone footage claiming to show Hamas "staging" the recovery of an Israeli hostage.

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North was a pioneering green voice who later challenged the movement he helped shape, championing progress, free thought and the value of hard-won scepticism

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People in Jamaica are waking up to the devastation left by Hurricane Melissa, as Prime Minister Andrew Holness declared the entire country a “disaster area".
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Donald Trump raised eyebrows with an awkward impression of Indian Prime Minister Narendra Modi during the Asia-Pacific Economic Cooperation (APEC) summit in South Korea.

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Local residents have voiced opposition to the Tooting Broadway project

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These are the restaurants and supermarkets where you can save this half-term

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Fabio Wardley has not closed the door of possibility on a rematch with Joseph Parker after stopping the Kiwi in the 11th round of their WBO interim heavyweight title fight.

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I’m expecting to see huge discounts on the iPad Pro, iPad Air and 11th-generation iPad this November

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There’s a better way to get your caffeine fix, from bean-to-cup to espresso machines

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From Claire Keegan's ‘Small Things Like These’ to Vincenzo Latronico's ‘Perfection’, these novellas are less than 200 pages

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Comedian has revealed singer is ‘not happy’ with his backstabbing antics on BBC game show

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Presenting duo unexpectedly revealed that they will be stepping away from series after the current season

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The McLaren driver sealed a terrific pole position in Mexico City, setting up his victory on Sunday

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The incident exposes the staffing pressures at the heart of Britain’s prison crisis

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Heavy rainfall and thunderstorms are forecast until Friday

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Israel carried out powerful strikes on Gaza on Tuesday after a soldier was reportedly killed and Hamas handed over the wrong remains

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Calculating the cost of raising kids is a complicated beast that raises many questions for academics to consider

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10 died and five missing after days of rain triggered floods and landslides

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The rise of walking football is offering older adults a new way to stay active through competition, connection and fun

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Video shows the damage done to Sangster International Airport in Jamaica after Hurricane Melissa made landfall, with officials declaring the entire country a “disaster area”.
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Holidaymakers Wendy and Steve Shirk said they were expecting "sunshine and roses" on a family trip in Jamaica, but found themselves spending the night in a shelter, as Hurricane Melissa made landfall on the island.
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This 12 day countdown is brimming with everyday staples

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A new study has found that young adults who exhibit higher levels of manipulative, self-centered, and callous personality traits tend to report having lower quality family interactions. The research, published in the Journal of Professional & Applied Psychology, suggests a distinct connection between these so called “Dark Triad” traits and the health of family dynamics.
Researchers have long been interested in how personality develops, often focusing on widely recognized models of personality. Recently, attention has shifted toward understanding the less socially desirable aspects of human nature, collectively known as the Dark Triad, which includes Machiavellianism, narcissism, and psychopathy. These traits are associated with behaviors that can strain social bonds, yet their specific impact within the family unit has been a less explored area.
The study’s authors wanted to examine this connection in a specific cultural and demographic context. They focused on young adults in Pakistan, a country where a large portion of the population falls within the 18 to 25 age range. This period is a formative time when an individual’s personality and perspective are still evolving, heavily influenced by their immediate environment, especially the family. By investigating this group, the researchers aimed to add a non-Western perspective to a field of study that has predominantly been centered on European and North American populations.
“The motivation for this study stemmed from the fact that this area remains largely understudied in Pakistan, leaving a significant research gap,” said study author Quratul Ain Arshad, who is currently a Bachelor of Laws student at the University of London.
“This topic represents a real-world issue that has not received the attention it deserves. I have personally observed several families affected by these dark traits, struggling to cope due to a lack of awareness and understanding. Through this research, I aimed to shed light on this issue so that individuals can better recognize what is happening to them and those around them and seek the help and guidance they need.”
To conduct their investigation, the researchers recruited a sample of 300 young adults between the ages of 18 and 25 from various universities and corporate offices in Lahore, Pakistan. Participation was voluntary, and the confidentiality of the responses was protected. Each participant completed two self-report questionnaires designed to measure different psychological constructs.
The first questionnaire was the Short Dark Triad scale, which assesses the three core traits. Machiavellianism is characterized by a manipulative and cynical worldview, narcissism involves a sense of grandiosity and entitlement, and psychopathy is marked by impulsivity and a lack of empathy. The second questionnaire was a modified version of the Family Assessment Device, which measures the quality of family interactions across several dimensions. These dimensions include problem solving, communication, assigned roles, emotional responsiveness, emotional involvement, and behavior control.
After collecting the data, the research team performed a statistical analysis to determine if there was a relationship between the scores for Dark Triad traits and the scores for family functioning. This type of analysis reveals whether two variables tend to move together, either in the same direction or in opposite directions. The study specifically tested four hypotheses about these potential connections.
The primary finding confirmed the researchers’ main prediction. There was a clear negative relationship between overall scores on the Dark Triad scale and the overall quality of family interaction. This indicates that as an individual’s levels of Machiavellianism, narcissism, and psychopathy increased, their reported level of healthy family functioning tended to decrease. This suggests that these aversive personality traits are indeed connected to difficulties within the family environment.
When the researchers examined the traits individually, the results were more nuanced. The connection between Machiavellianism and a family’s general functioning was found to be very weak and not statistically meaningful. This suggests that a person’s tendency toward manipulation may not have a direct, measurable link to their perception of the family’s overall effectiveness.
A different pattern emerged for psychopathy. This trait was found to have a modest but statistically significant negative relationship with what is known as “affective responsiveness,” which is a family’s capacity to respond to situations with appropriate emotions. In simple terms, young adults with higher psychopathy scores were more likely to come from families they perceived as being less emotionally attuned.
The final hypothesis looked at the link between narcissism and “affective involvement,” which refers to the extent to which family members show interest and care for one another. Much like the finding for Machiavellianism, this connection was also very weak and not considered statistically significant. This outcome suggests that a person’s level of narcissism may not be directly tied to the degree of emotional investment they perceive within their family.
“The key takeaway from this study is the importance of self-awareness,” Arshad told PsyPost. “Every individual should strive to understand their own personality traits and reflect on their behaviors. By doing so, they can not only improve themselves but also better support those around them who may exhibit these traits.”
The study did have some limitations. The findings are based on self-report questionnaires, which means participants’ responses could have been influenced by a desire to present themselves or their families in a positive light. The sample was also drawn exclusively from one city in Pakistan and was limited to young adults, which means the results might not be generalizable to other age groups or cultures.
For future research, the authors suggest that longitudinal studies, which follow individuals over a long period, could provide deeper insight into how Dark Triad traits and family dynamics influence each other over time. Using multiple methods of assessment, beyond just self-reports, could also help create a more complete picture of these complex interactions. Such work could help in designing interventions aimed at improving family relationships and promoting healthier personality development.
“The size of the sample used in this study is not big enough to represent the total young adult population in Pakistan, but this study is significant in understanding how these traits shape interactions on a microlevel,” Arshad said. “The effect of this study is such that it will help researchers dig towards the developmental aspects of these traits and also conduct longitudinal studies in future to understand the implications of the Dark Triad traits in both older and younger populations than young adults.”
The study, “The Relationship Between Dark Triad and Quality of Family Interaction among Young Adults,” was authored by Quratul Ain Arshad, Uzma Ashiq, and Khadija Malik.

A new study has found that a student team’s collective emotional intelligence is a significant predictor of its success in collaborative problem-solving. Specifically, the abilities to understand and manage emotions were linked to both better teamwork processes and a higher quality final product. The findings, which also examined the role of personality, were published in the Journal of Intelligence.
While individual intelligence and personality traits like conscientiousness are known to predict individual success, much less is understood about what drives performance when students are required to work together in teams. This form of learning, known as collaborative problem solving, is increasingly common in modern education, prompting a need to identify the skills and dispositions that help groups succeed.
The study’s authors aimed to investigate how two sets of characteristics, emotional intelligence and the Big Five personality traits, might influence the performance of high school students working in small groups.
“This study was actually part of a larger project, called PEERSolvers, in which we were looking for scientifically supported ways to enhance the quality of students’ collaborative problem solving,” said study author Ana Altaras, a full professor in the Department of Psychology at the University of Belgrade.
“This naturally led us to explore the role played by emotional intelligence and personality in student collaborations. Having previously conducted two systematic reviews (Altaras et al., 2025; Jolić Marjanović et al., 2024), we knew that both emotional intelligence and the Big Five personality traits indeed act as ‘deep-level composition variables’ shaping the processes and outcomes of teamwork in higher-education and professional contexts.”
“We also knew that both variable sets contribute to the prediction of individual students’ school performance. However, we also saw an obvious research gap when it comes to exploring their joint effects on the performance of student teams in high school. Hence, we digged into this topic.”
The researchers recruited 162 tenth-grade students from twelve secondary schools. The students first completed assessments to measure their emotional intelligence and personality. Emotional intelligence was evaluated using the Mayer-Salovey-Caruso Emotional Intelligence Test, a performance-based test that measures a person’s actual ability to perceive, use, understand, and manage emotions. Personality was assessed with the Big Five Inventory, a questionnaire that measures neuroticism, extraversion, openness, agreeableness, and conscientiousness.
Following the initial assessments, the students were organized into 54 teams of three. Each team was then tasked with solving a complex social problem over a 2.5-hour session. The problems were open-ended and required creative thinking, covering topics such as regulating adolescent media use or balancing economic development with ecological protection. The entire collaborative session for each team was video-recorded, and each team submitted a final written solution.
Trained observers analyzed the video recordings to rate the quality of each team’s collaborative processes. They assessed four distinct aspects of teamwork: the exchange of ideas and information, the emotional atmosphere and level of respect, how the team managed its tasks and time, and how it managed interpersonal relationships and conflicts. In a separate analysis, a different set of evaluators rated the quality of the team’s final written solution based on criteria like realism, creativity, and the strength of its arguments.
The researchers found that emotional intelligence was a strong predictor of team performance. Teams with higher average scores in understanding and managing emotions showed superior teamwork processes. This improvement in collaboration, in turn, was associated with producing a better final solution. The ability to understand emotions also appeared to have a direct positive effect on the quality of the written solution. This suggests that knowledge about human emotions was directly applicable to solving the complex social problems presented in the task.
“Looking at the results of our study, emotional intelligence–particularly its ‘strategic branches’ or the ability to understand and manage emotions–had a lot to do with students’ performance in collaborative problem solving,” Altaras told PsyPost. “Student teams with higher team-average emotional intelligence engaged in a more constructive exchange of ideas, had a friendlier way of communicating, and were more efficient in managing both task and relationship-related challenges throughout the problem-solving process. Ultimately, these teams also came up with better solutions to the problems at hand. In sum, students’ emotional intelligence seems to contribute substantially to the quality of their collaborative problem solving.”
The role of personality traits was more nuanced and produced some unexpected results. As expected, the personality trait of openness to experience was positively associated with the quality of the final solution. This connection is likely due to the creative and open-ended nature of the problem-solving task.
But teams with a higher average level of neuroticism, a trait associated with anxiety and stress, were actually better at managing their tasks. The researchers propose that a tendency toward distress may have prompted these teams to plan their approach more diligently. In contrast, teams with higher average extraversion were less effective at relationship management, perhaps because they were less inclined to formally address group tensions.
“Contrary to our expectations, we found only few statistically significant associations between the Big Five personality traits and the quality of students’ collaboration,” Altaras said. “Moreover, the effects that did surface as significant–a positive effect of neuroticism on task management and a negative effect of extraversion on relationship management–seem counterintuitive in terms of their direction.”
When the researchers examined emotional intelligence and personality together in a combined model, emotional intelligence emerged as the more consistent and powerful predictor of overall performance. The contribution of personality was largely limited to the link between neuroticism and task management, suggesting emotional skills were more influential in this context.
As with all research, the study does have some limitations. The sample size was relatively small due to the intensive nature of analyzing hours of video footage. The teams were also composed of students of the same gender, which might not fully represent the dynamics of mixed-gender groups common in schools. Additionally, the study did not measure the students’ general academic intelligence, which could also be a factor in their performance.
“In our defense, emotional intelligence has already been shown to have incremental predictive value in so many instances–including the prediction of students’ individual school performance–that we would not expect it to lose much of its predictive weight when analyzed concurrently with academic abilities,” Altaras noted. “Still, the picture would be more complete had we been able to also test participants’ academic intelligence and include this variable as another potential predictor of their performance in collaborative problem solving.”
For future research, the authors suggest exploring these dynamics in larger and more diverse student groups. It would also be informative to see if these findings hold when teams are faced with different kinds of problems, such as those that are less social and more technical in nature. Examining these factors could provide a more complete picture of the interplay between ability, personality, and group success in educational settings.
“Within the PEERSolvers project, we have already developed a training (PDF) that targets, among other things, students’ emotional intelligence abilities and knowledge of personality differences, hoping to enhance the quality of their collaborative problem solving in this manner,” Altaras said. “In an experimental study, the training was shown to make a difference–i.e., to have a positive effect on students’ performance in collaborative problem solving (Krstić et al., 2025)–and we are now looking forward to having it more widely implemented in schools. When it comes to further research, we will certainly continue to explore the role of emotional intelligence abilities in the educational context, considering the performance and well-being of both students and teachers.”
The study, “Emotional Intelligence and the Big Five as Predictors of Students’ Performance in Collaborative Problem Solving,” was authored by Ana Altaras, Zorana Jolić Marjanović, Kristina Mojović Zdravković, Ksenija Krstić, and Tijana Nikitović.

Bluey is a popular Halloween costume this year.

In a rare interview, former authoritarian leader Sheikh Hasina tells The Independent she is not to blame for bloodshed during her ousting, and calls her trial in absentia a ‘sham’

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At Bawah Reserve in Indonesia's Anambas Islands, Annabel Grossman finds a hotel where guests live within nature rather than displacing it

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Pulis’ Stoke City side have also been recognised by Pep Guardiola as pioneers of the trend

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The exiled mayor of Enerhodar, close to Ukraine’s biggest nuclear power station fears tells Sam Kiley in Zaporizhzhia he is afraid of an ecological catastrophe

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Exclusive: Hamish Falconer has spoken to The Independent on Gaza and why cutting international aid has not made the migrant crisis worse

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Coffee makers and noise-cancelling headphones are among the items up for grabs in this year’s mystery box

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The stalwart’s second collaboration with the iconic British designer is sure to sell out

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Keen to see more of the Czech Republic than just its romantic capital, Chris Wilson makes his way out to an ancient spa city to combine excitement with relaxation on a dual-destination break

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Paul Angliss was diagnosed after his neck broke when he stubbed his toe

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Having always hated Halloween, Rosamund Hall plucks up the courage to travel to Pluckley in Kent where ghostly goings-on are prolific

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The warning is likely to harm prospects for the OBR upgrading its forecast for economic growth from construction

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Britain urged to pressure Vietnam over her release

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Everything you need to know ahead of the Carabao Cup quarter-final draw

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Massa’s case against F1, the FIA and Ecclestone over the ‘Crashgate’ scandal starts on Wednesday in London

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All you need to know as Chelsea visit Molineux in the fourth round of the Carabao Cup

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Next episode of main series will arrive a whole 19 months after Ncuti Gatwa’s final episode in May 2025

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Emma Thompson and Ruth Wilson are superb in this labyrinthine, nervy and archly funny conspiracy thriller, adapted from Mick Herron’s debut novel. Oxford hasn’t seen this many murders since Inspector Morse

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As the ‘Die My Love’ actor reveals she relied on the AI service during a vulnerable moment, Olivia Petter asks why we all started instinctively relying on robots, and what it says about the future

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Forecasters expect catastrophic damage from the Category 4 storm in Santiago de Cuba and nearby areas

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The storm made landfall in the southwestern part of Jamaica with destructive winds and heavy rain

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Putin's forces outnumber Ukrainian troops by eight to one in strategic hub of Pokrovsk, says Zelensky

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Finding indicates extinct forms of mosquitoes coexisted with modern ones during the dinosaur era

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The Netherlands elections take place against a backdrop of protests across the country against new asylum-seeker centres

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Trump is expected to meet with Xi later this week in South Korea

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Trump admitted he is not allowed to run for a third term, but told reporters Tuesday night, ‘We'll see what happens’

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Demand for dog meat, also locally known as ‘Scooby Doo’, has declined due to younger generation's penchant for keeping dogs as pets

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The event, attended by Trump and First Lady Melania, was to celebrate the Navy’s 250th birthday

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They were written by two soldiers who died not long afterwards

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A new approach emerges.
Time to get creative.
Where ice meets rock (or doesn't).
Scientists try to make heads or tails of it.
Division within the GOP caucus over food stamps could give Democrats a key opening to ramp up the pressure on Republicans to make concessions and earn their votes to end the shutdown, John Bowden and Eric Garcia report

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Two thirds of hospices in England reported a financial deficit in 2023/24

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Savage aid cuts and a narrow focus on cost to the taxpayer risked undermining ‘the very reason the aid budget exists’, the International Development Committee says
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The Stroke Association said only a third of patients are getting the recommended aftercare

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Pancreatic Cancer UK said the launch of the trial was “the most significant step toward a life-saving breakthrough in 50 years”

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The conservationists have plans to boost wildlife, restore bogs and champion nature-friendly farming

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The move has been hailed by officials as the biggest change to sexual health services since the 1960s

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Springsteen: Deliver Me From Nowhere follows the musician as he crafts his seminal country-folk album

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UK regional airline Eastern Airways has “suspended operations”, with passengers who had booked with the airline being told not to travel to airports.

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The Mira Sorvino-Lisa Kudrow comedy is the latest Nineties film to get the musical treatment

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The Frontera name has been brushed off and put on a great SUV that’s cheaper than its petrol equivalent

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Brazilian security forces launched a massive daylong operation on drug gangs in Rio de Janeiro’s favelas, setting off fierce gun battles that left dozens dead and many wounded, in what officials called one of the largest and most violent police actions in recent years.

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The 15-year-old is set to feature in the fourth round of the Carabao Cup

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The effects of the president’s sweeping global tariffs have meant that the Sinterklaas celebrations in Rhinebeck have been canceled for the first time in 26 years

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A new study has demonstrated that a virtual reality game can successfully teach people a breathing technique to regulate their physiological stress responses. This training led to improved biological markers of stress regulation during a tense virtual experience, suggesting such games could be a practical way to practice stress management skills. The research was published in the journal Psychophysiology.
While physiological regulation strategies like paced breathing are known to be effective, they are typically learned and practiced in calm, controlled environments. This setting is very different from the high-stress situations where such techniques are most needed, which may make it difficult for people to apply their training in real life. The study authors proposed that virtual reality could offer a unique solution by providing an immersive platform to both teach a regulation skill and then immediately create a stressful context in which to practice it.
The project involved two separate studies. The first study was designed as a proof of concept to see if the approach was feasible. Researchers recruited healthy adult participants and first recorded their baseline heart rate, heart rate variability, and breathing rate while they sat quietly. Heart rate variability is a measure of the variation in time between consecutive heartbeats, with higher variability often indicating better physiological regulation and a greater capacity to cope with stress.
Following the baseline recording, participants put on a virtual reality headset and played a training game. In this game, they found themselves on a boat in a calm sea and were guided through a slow, paced breathing exercise. On-screen prompts instructed them to inhale for five seconds, hold for five seconds, and exhale for five seconds, with the goal of achieving a slow breathing rate of four breaths per minute. Immediately after this training, they were immersed in a stressful game set in a dark dungeon. The objective was to avoid being detected by a creature that could supposedly hear their heartbeats.
A biofeedback display, visible at all times, showed participants a simplified “stress score” based on their heart rate. A green light indicated they were safe, while amber and red lights signaled increasing danger of being discovered. To succeed, participants had to use the breathing technique they had just learned to keep their heart rate down.
The study found that participants were able to apply the breathing technique effectively. Their breathing rate during the stressful dungeon game was significantly lower than their initial resting rate, showing they were following the training. Although their heart rate naturally increased from the stress of the game, their heart rate variability also increased compared to their baseline levels. This suggested an enhanced state of physiological regulation, likely driven by the controlled breathing.
The second study was designed to more formally test the effectiveness of the training by comparing a trained group to an untrained control group. Both groups attended two sessions, separated by about a week. In the first session, all participants experienced an initial stressful virtual reality scenario involving an intruder in a house. This was done to establish a baseline measure of each person’s stress reactivity. After this initial stressor, only the training group played the boat game twice to learn the breathing technique.
When they returned for the second session, the training group received a refresher by playing the boat game two more times. Then, both the trained and untrained groups played the same stressful dungeon game from the first study. The results showed a clear effect of the training. During the dungeon game, the trained group had a significantly lower breathing rate and a significantly higher heart rate variability compared to the untrained control group.
When the researchers compared physiological responses across the two different stressors, they found a notable interaction. The trained group showed a significant improvement in their heart rate variability from the pre-training “intruder” stressor to the post-training “dungeon” stressor. This pattern of improvement was not observed in the control group, providing stronger evidence that the breathing training was responsible for the effect.
An unexpected observation was that participants in the trained group reported feeling subjectively more stressed than the control group. The authors speculate this could be related to a sense of performance anxiety, as the trained group was aware their application of the technique was being evaluated.
The researchers acknowledged some limitations in their work. The first study was affected by technical issues with the respiratory measurement equipment, which led to the loss of some data. Additionally, a minor coding error in the training game meant that the boat’s speed was incorrectly linked to heart rate, though the authors believe this was unlikely to have affected the learning of the breathing pattern.
Future research could explore the surprising finding that physiological regulation did not align with subjective feelings of stress. It may also examine whether skills learned in an unrealistic game scenario can be generalized to manage stress in real-world situations.
The study, “Using a virtual reality game to train biofeedback-based regulation under stress conditions,” was authored by Lucie Daniel-Watanabe, Benjamin Cook, Grace Leung, Marino Krstulović, Johanna Finnemann, Toby Woolley, Craig Powell, and Paul Fletcher.

The first generation at greater risk of developing tumors than their parents.
"It's a bit of a terrifying situation."
Frank believes that the competitions semi-finals should be settled over one leg

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Trump is due to arrive in the South Korean city of Gyeongju on Wednesday to join other heads of state and business leaders attending the Apec forum

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The Italian also voiced his support for manager Arne Slot’s decision to offer him limited minutes last season, saying he ‘wasn’t up to speed’

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Alexander Dennis Jr., 33, allegedly tried to run over his date twice with a stolen vehicle

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Wrexham 1-2 Cardiff: The visitors emerged as deserved winners from a first meeting of the two Welsh clubs in more than two decades

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Authorities have evacuated tens of thousands of people from flooded areas

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The Premier League team had to come from behind at Adams Park

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The truck carrying Rehsus monkeys from Tulane University in New Orleans crashed on Interstate 59

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25 states warn of imminent ‘crisis’ for millions if the federal government won’t tap into emergency funds

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The Mariners famously beat Manchester United in the second round but were no match for Keith Andrews’ side

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New research shows chronic stress increases inflammation and can even “awaken” dormant tumour cells

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The massive raid by thousands of cops followed a year of investigation into the criminal group

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There have currently been no reported illnesses as a result of the choking hazard, the FDA reports

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Business development executive Toby was the latest contestant to leave the show

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England 3-0 Australia: Aggie Beever-Jones and Georgia Stanway also scored in a 3-0 win marred by Michelle Agyemang’s injury

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Agyemang was in tears as she was stretchered off just 18 minutes after coming on for England as a substitute

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Thompson went off about the technology during her Monday appearance on Stephen Colbert’s late night show

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An expert has issued a warning to those considering swapping their pension providers for lower fees.

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Editorial: With a £20bn Budget black hole to plug, the chancellor has no option but to break Labour’s manifesto pledge – tinkering in the margins will hurt growth, while slashing public spending will lead to electoral ruin

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Norrie battled from a set down to win 4-6 6-3 6-4 and hailed the win as the biggest victory of his career

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Fathers who are over the age of 35 are more likely to have children with adverse birth outcomes, experts warn

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Wardley’s team have suggested Usyk may be past his best, but is that really true of the unbeaten, undisputed king?

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‘Hunger Games’ star said her behavior in old interviews was a ‘defense mechanism’

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An Egyptian tortoise and a Northern Spider tortoise were stolen from the Indianapolis Zoo earlier this month

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One teen told police he spoke briefly with the man but otherwise had no previously interactions with him

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Tom Daley has revealed his oldest son’s adorable reaction to his The Celebrity Traitors elimination.

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Tom Daley has reacted to some of his viral The Celebrity Traitors moments.

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Hurricane Melissa made landfall Tuesday in Jamaica

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Explosions could be seen in the Gaza night sky after Benjamin Netanyahu announced that he has ordered “powerful strikes” in the enclave.

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Strictly Come Dancing’s Amber Davies has broken her silence on her appearance in the dance-off on Sunday (26 October), calling the experience “awful”.

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New research suggests that the desire for a psychologically rich life, one filled with varied and perspective-altering experiences, is a significant driver behind why people choose activities that are intentionally unpleasant or challenging. The series of studies, published in the journal Psychology & Marketing, indicates that this preference is largely fueled by a motivation for personal growth.
Researchers have long been interested in why people sometimes opt for experiences that are not traditionally pleasurable, such as watching horror movies, eating intensely sour foods, or enduring grueling physical challenges. This behavior, known as counterhedonic consumption, seems to contradict the basic human drive to seek pleasure and avoid pain. While previous explanations have pointed to factors like sensation-seeking or a desire to accumulate a diverse set of life experiences, researchers proposed a new motivational framework to explain this phenomenon.
They theorized that some individuals are driven by a search for psychological richness, a dimension of well-being distinct from happiness or a sense of meaning. A psychologically rich life is characterized by novelty, complexity, and experiences that shift one’s perspective. The researchers hypothesized that this drive could lead people to embrace discomfort, not for the discomfort itself, but for the personal transformation and growth such experiences might offer.
To investigate this idea, the researchers conducted a series of ten studies involving a total of 2,275 participants. In an initial study, participants were presented with a poster for a haunted house pass and asked how likely they would be to try it. They also completed questionnaires measuring their desire for a psychologically rich life, as well as their desire for a happy or meaningful life and their tendency toward sensation-seeking.
The results showed a positive relationship between the search for psychological richness and a preference for the haunted house experience. This connection remained even when accounting for the other factors.
To see if this finding extended beyond fear-based activities, a subsequent study presented participants with a detailed description of an intensely sour chicken dish. Again, individuals who scored higher on the scale for psychological richness expressed a greater likelihood of ordering the dish.
A third study solidified these findings in a choice-based scenario, asking participants to select between a “blissful garden” experience and a “dark maze” designed to be disorienting. Those with a stronger desire for psychological richness were more likely to choose the dark maze, a finding that held even after controlling for general risk-taking tendencies.
Having established a consistent link, the research team sought to determine causality. In another experiment, they temporarily prompted one group of participants to focus on psychological richness by having them write about what it means to make choices based on a desire for interesting and perspective-changing outcomes. A control group wrote about their daily life. Afterward, both groups were asked about their interest in a horror movie streaming service.
The group primed to think about psychological richness showed a significantly higher preference for the service, suggesting that this mindset can directly cause an increased interest in counterhedonic experiences.
The next step was to understand the psychological process behind this link. The researchers proposed that a focus on self-growth was the key mechanism. One study tested this by again presenting the sour food scenario and then asking participants to what extent their choice was motivated by a desire for self-discovery and personal development. A statistical analysis revealed that the desire for self-growth fully explained the connection between a search for psychological richness and the preference for the sour dish.
To ensure self-growth was the primary driver, another study tested it against an alternative explanation: the desire to create profound memories. While a rich life might involve creating interesting stories to tell, the results showed that self-growth was the significant factor explaining the choice for the sour dish, whereas the desire for profound memories was not.
Further strengthening the causal claim, another experiment first manipulated participants’ focus on psychological richness and then measured their self-growth motivation. The results showed that the manipulation increased a focus on self-growth, which in turn increased the preference for the counterhedonic food item.
A final, more nuanced experiment provided further support for the self-growth mechanism. In this study, the researchers manipulated self-growth motivation directly. One group was asked to write about making choices that foster personal growth, while a control group was not. In the control condition, the expected pattern emerged: people higher in the search for psychological richness were more interested in the sour dish.
However, in the group where self-growth was made salient, preferences for the sour dish increased across the board. This effectively reduced the predictive power of a person’s baseline level of psychological richness, indicating that when the need for self-growth is met, the underlying trait becomes less of a deciding factor.
The research has some limitations. Many of the studies relied on hypothetical scenarios and self-reported preferences, which may not perfectly reflect real-world consumer behavior. The researchers suggest that future work could use field experiments to observe actual choices in natural settings. They also note that cultural differences could play a role, as some cultures may place a higher value on experiences of discomfort as a pathway to wisdom or personal development. Exploring these boundary conditions could provide a more complete picture of this motivational system.
The study, “The Allure of Pain: How the Quest for Psychological Richness Drives Counterhedonic Consumption,” was authored by Sarah Su Lin Lee, Ritesh Saini, and Shashi Minchael.





With a 60mm lift, skid plates, new dampers, and custom lighting, the 2026 Passport concept previews Honda’s most capable SUV yet.

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Honda dressed up a Passport TrailSport in in its finest off-roading finery.

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England 3-0 Australia: The Lionesses repeated their heroics of the 2023 World Cup semi-final to beat the Matildas at Pride Park

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At least 60 Palestinians killed as Israel launches renewed attack on Gaza

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Britons urged to alert Foreign Office of presence on island as ‘trillions of gallons’ of water set to fall amid power cuts

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The incident unfolded Saturday in Chicago’s Old Irving Park neighborhood, where residents say federal agents disrupted a children’s Halloween parade

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The Microsoft founder and billionaire claimed that people will be able to ‘live and thrive in most places on Earth for the foreseeable future’

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Plane Talk: As a former BBC editor is denied boarding due to his lack of a medical note, the health requirements for flying appear to be under scrutiny

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Radford was appointed as Steve Tandy’s successor in the Scotland setup

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The chancellor may still be considering a cut to cash ISA savings limits, but there are fears it would not encourage people to start investing
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Wrexham 1-2 Cardiff: Cardiff sealed their spot in the last eight with a deserved win

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The Zebulon man’s 3-year-old son was found unharmed, while he allegedly killed his four other kids
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Claire Jones, 52, is now helping other women going through the menopause to regain their confidence through her innovative method

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Greg Bovino is being hauled to court every day after his officers are accused of gassing neighborhoods and threatening protesters with ‘you’re dead, liberal’ taunts

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Adeleye will return to the ring in December alongside Lawrence Okolie, on a card in Nigeria against an unconfirmed opponent

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This spice is great in holiday cookies - but have huge health benefits as well

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The Israeli PM announced its plans attack shortly after claiming Hamas had opened fire at Israeli forces in southern Gaza

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As far as we know, humans are the only species that choose to fight against our biological presets

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John Ashby, 32, has been charged with one count of rape and sexual assault in relation to the attack

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The plan represents one of the most ambitious U.S. investments in atomic energy in decades

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‘Freaky Friday’ star made headlines last month after she broke down in tears over Kirk’s death despite her opposing views

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Brigitte Macron’s daughter told a Paris court about the impact of alleged cyberbullying on her mother and her family

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The new As Ever products were launched Tuesday

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Nearly 20,000 pension savers have urged the government to rule out two key changes

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It uses a blend of natural ingredients to ease swelling and discomfort after meals

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The skeletons of the duck-billed dinosaurs, Edmontosaurus Annectens – which lived more than 66 million years ago in the late Cretaceous period – were unearthed in 1908 in a ravine area of east-central Wyoming

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O’Neill has replaced Brendan Rodgers in the Celtic dugout alongside Shaun Maloney

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From Malta to Morocco, these are the best sun-soaked shores to beat the winter blues

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The comedians both left the show ahead of season 51

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Steve Borthwick is keen to increase England’s positional flexibility

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Bizarre remarks came during rambling speech aboard forward-deployed aircraft carrier

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The FAA is about 3,500 air traffic controllers short of targeted staffing levels

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Barack wore the controversial outfit during a White House briefing in 2014

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Opposition slams administration for removing restrictions on firearms exports, calling move ‘a gift to violent cartels and drug traffickers’

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Motsi Mabuse has revealed that she does not want her sister Oti to be a new Strictly Come Dancing host, saying she “wouldn’t let her do it”

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Economists say trying to balance the books by raising smaller taxes risks ‘unnecessary amounts of economic damage’

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Ravik was made a new professional dancer on the show for season 34

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Saying he was ‘flattered’ by all of the media attention the speculation has received, Bret Baier added that ‘we’ll see what happens at the end’ of his Fox News contract.

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Whether you’re after entry-level or heavy-duty tools, these are up to the task

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Newsom occupies second place with 15% of voters choosing him as their preferred presidential candidate, losing out to former Transport Secretary Pete Buttigieg, who has 19%

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Usyk is set to face Wardley next, after the British heavyweight fought from behind to stop Joseph Parker
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Paul is currently making preparations for his controversial ‘exhibition’ bout with Gervonta Davis on 14 November

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Parents ‘underwhelmed’ by the high prices and ‘minimal effort’ put into displays at Cardiff’s Halloween Festival

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Catherine Corcoran says she has not been paid in full for her role in Damien Leone’s horror franchise

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The 43-year-old retired from Test cricket last July having taken 704 wickets, the most by any seamer

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Over 8,000 flights were delayed on Sunday due to massive staff shortages caused by the government shutdown

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Watch a live view of Hurricane Melissa making landfall in Jamaica on Tuesday (28 October).

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British Pasture Leather’s MADE WITH collection is a collaboration connecting farmers, designers, and makers to restore value to the land and everything that grows from it – Caroline Garland explores whether these materials could provide a compelling alternative to conventional leather

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Global conflicts, pushback on climate action, and a retrenchment from values of Diversity, Equity, and Inclusion (DEI) are also all seen as key threats to global development

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All of Caribbean islands airports shut as world’s strongest storm of year so far set to make landfall

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Select members of the media were able to watch the sequel on Monday

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Tech boss sought out attorney general for advice on best to speak to president, new book claims

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Trump has long been toying with the idea of a third term, even though it is prohibited by the Constitution

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Claims of “flag jacking” go back to at least the Vietnam War

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Ballad of a Small Player sees Colin Farrell take on one of his most physical roles yet – a high-stakes gambler haunted by his past as his debts close in. We sit down with Farrell and director Edward Berger (Conclave, All Quiet on the Western Front) to explore how they captured the film’s sensory chaos, and how a story takes on a life of its own once it’s out in the world.

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An analysis of the China Health and Retirement Longitudinal Study data found that individuals with more severe depressive symptoms tend to report higher levels of social isolation at a later time point. In turn, individuals who are more socially isolated tend to report slightly worse cognitive functioning. Analyses showed that social isolation mediates a small part of the link between depressive symptoms and worse cognitive functioning. The paper was published in the Journal of Affective Disorders.
Depression is a mental health disorder characterized by persistent sadness, loss of interest or pleasure, and feelings of hopelessness that interfere with daily functioning. It adversely affects the way a person thinks, feels, and behaves. It can lead to difficulties in work, relationships, and self-care.
People with depression may experience fatigue, changes in appetite, and sleep disturbances. Concentration and decision-making can become harder, reducing productivity and motivation. Physical symptoms such as pain, headaches, or digestive issues may also appear without clear medical causes.
Depression can diminish the ability to enjoy previously pleasurable activities, leading to social withdrawal. This isolation can worsen depressive symptoms, creating a cycle of loneliness and despair. Social isolation itself is both a risk factor for developing depression and a common consequence of it.
Study author Jia Fang and her colleagues note that depressed individuals also tend to show worse cognitive functioning. They conducted a study aiming to explore the likely causal direction underpinning the longitudinal association between depressive symptoms and cognitive decline, and a possible mediating role social isolation has in this link among Chinese adults aged 45 years and above. These authors hypothesized that social isolation mediates the association between depressive symptoms and cognitive function.
Study authors analyzed data from the China Health and Retirement Longitudinal Study (CHARLS). CHARLS is a nationally representative longitudinal survey of Chinese residents aged 45 and above. This analysis used CHARLS data from three waves in 2013, 2015, and 2018, including a total of 9,220 participants. 51.4% were women. Participants’ average age was 58 years.
The authors of the study used data on participants’ depressive symptoms (the 10-item Center for Epidemiologic Studies Depression Scale), social isolation, and cognitive function (assessed with tests of contextual memory and mental integrity). A social isolation score was calculated based on four factors: being unmarried (single, separated, divorced, or widowed), living alone, having less than weekly contact with children (in person, via phone, or email), and not participating in any social activities in the past month.
Results showed that depressive symptoms were associated with subsequent social isolation. Social isolation, in turn, was associated with subsequent worse cognitive functioning. Further analyses showed that social isolation partially mediated the link between depressive symptoms and cognitive functioning, explaining 3.1% of the total effect.
The study authors concluded that the association between depressive symptoms and cognitive function is partially mediated by social isolation. They suggest that public health initiatives targeting depressive symptoms in older adults could reduce social isolation and help maintain cognitive health in middle-aged and older adults in China.
The study sheds light on the nature of the link between depressive symptoms and cognitive functioning. However, it should be noted that the design of the study does not allow definitive causal inferences to be derived from these results. Additionally, social isolation was assessed through self-reports, leaving room for reporting bias to have affected the results. Finally, the reported mediation effect was very modest in size, indicating that the link between depression and cognitive functioning depends much more on factors other than social isolation.
The paper, “Social isolation mediates association between depressive symptoms and cognitive function: Evidence from China Health and Retirement Longitudinal Study,” was authored by Jia Fang, Wencan Cheng, Huiyuan Li, Chen Yang, Ni Zhang, Baoyi Zhang, Ye Zhang, and Meifen Zhang.

A new study finds that single adults in both the United States and Japan report lower well-being than their married peers. The research suggests that the influence of family support and strain on this health and satisfaction gap differs significantly between the two cultures. The findings were published in the journal Personal Relationships.
Researchers conducted this study to better understand the experiences of single adults outside of Western contexts. Much of the existing research has focused on places like the United States, where singlehood is becoming more common and accepted. In these individualistic cultures, some studies suggest single people may even have stronger connections with family and friends than married individuals.
However, in many Asian cultures, including Japan, marriage is often seen as a more essential part of life and family. This can create a different set of social pressures for single people. The researchers wanted to investigate whether these cultural differences would alter how family relationships, both positive and negative, are connected to the well-being of single and married people in the U.S. and Japan.
“I’ve always been curious about relationship transitions and singlehood lies in this awkward space where people are unsure if it really counts as an actual ‘relationship stage’ per se,” said study author Lester Sim, an assistant professor of psychology at Singapore Management University.
“Fortunately, the field is starting to recognize singlehood as an important period and it’s becoming more common, yet people still seem to judge singles pretty harshly. I find that kind of funny in a way, because it often reflects how we judge ourselves through others. Coming from an Asian background, I also wondered if these attitudes toward singlehood might play out differently across cultures, especially since family ties are so central in Asian contexts. That curiosity really sparked this project.”
To explore this, the research team analyzed data from two large, nationally representative studies: the Midlife in the U.S. (MIDUS) study and the Midlife in Japan (MIDJA) study. The combined sample included 4,746 participants who were 30 years of age or older. The researchers focused specifically on individuals who identified as either “married” or “never married,” and they took additional steps to exclude participants who were in a cohabiting or romantic relationship despite being unmarried.
Participants in both studies answered questions at two different points in time. The first wave of data included their marital status, their perceptions of family support, and their experiences of family strain. Family support was measured with items asking how much they felt their family cared for them or how much they could open up to family about their worries. Family strain was assessed with questions about how often family members criticized them or let them down.
At the second wave of data collection, participants reported on their well-being. This included rating their overall physical health on a scale from 0 to 10 and their satisfaction with life through a series of six questions about different life domains. The researchers then used a statistical approach to see how marital status at the first time point was related to well-being at the second time point, and whether family support and strain helped explain that relationship.
Across the board, the results showed that single adults in both the United States and Japan reported poorer physical health and lower life satisfaction compared to their married counterparts. This finding aligns with a large body of previous research suggesting that marriage is generally associated with better health outcomes.
When the researchers examined the role of family dynamics, they found distinct patterns in each country. For American participants, being married was associated with receiving more family support and experiencing less family strain. Both of these family factors were, in turn, linked to higher well-being. This suggests that for Americans, the well-being advantage of being married is partially explained by having more supportive and less tense family relationships.
The pattern observed in the Japanese sample was quite different. Single Japanese adults did report experiencing more family strain than married Japanese adults. Yet, this higher level of family strain did not have a significant connection to their physical health or life satisfaction later on.
“Family relationships matter a lot for everyone, whether you’re single or married, but in different ways across cultures,” Sim told PsyPost. “We found that singles in both the US and Japan reported lower well-being, in part because they experienced more family strain and less support (differentially across cultures). So even though singlehood is becoming more common, it still carries social and emotional costs. I think this shows how important it is to build more inclusive environments where singles feel equally supported and valued.”
Another notable finding from the Japanese sample was that there was no significant difference in the amount of family support reported by single and married individuals. While family support did predict higher life satisfaction for Japanese participants, it did not serve as a pathway explaining the well-being gap between single and married people in the way it did for Americans.
“I honestly thought the patterns would differ more across cultures,” Sim said. “I expected singles in Western countries to feel more accepted, and singles in Asia to rely more on family support and report greater strain; but neither of the latter findings turned out to be the case. It seems that, across the board, social norms around marriage still shape how people experience singlehood and well-being.”
The researchers acknowledged some limitations of their work. The definition of “single” was based on available survey questions and could be refined in future studies with more direct inquiries about relationship status.
“We focused only on familial support and strain because family is such a big part of East Asian culture,” Sim noted. “But singlehood is complex: friendships, loneliness, voluntary versus involuntary singlehood, and how satisfied people feel being single all matter too. We didn’t examine these constructs in the current study because there is existing work on this topic, so I wanted to bring more focus onto the family (especially with the cross-cultural focus). Future work should dig into those other layers and examine how they interact to shape the singlehood experience.”
It would also be beneficial to explore these dynamics across different age groups, as the pressures and supports related to marital status may change over a person’s lifespan. Such work would help create a more comprehensive picture of how singlehood is experienced around the world.
“I want to keep exploring how culture shapes the meanings people attach to relationships and singlehood,” Sim explained. “Long term, I hope this work helps shift the narrative away from the idea that marriage is the default route to happiness, and shift toward recognizing that there are many valid ways to live a good life.”
“Being single isn’t a problem to be fixed. It’s a meaningful, often intentional part of many people’s lives. The more we understand that, the closer we get to supporting well-being for everyone, not just those who are married.”
The study, “Cross-Cultural Differences in the Links Between Familial Support and Strain in Married and Single Adults’ Well-Being,” was authored by Lester Sim and Robin Edelstein.

Biology isn't that simple.






The prototype system can generate enough electricity for almost 1,900 miles of annual driving and aims to cut reliance on the grid.

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A closer look at Nissan’s solar power generation system

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The 20-year-old Texan will serve as reserve driver through 2026 after impressing in Formula 2 and free-practice sessions.
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New four-banger makes 324 hp, carryover PHEV 4xe maintains 375 hp.

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Jeep simplifies the Grand Cherokee lineup with four-cylinder and PHEV powertrains.

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Kardashian suffered a ‘little aneurysm’ reportedly due to stress

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A 22-year-old Afghan national – who arrived in the UK in a lorry before being granted asylum in 2022 – was arrested at the scene

State Attorney General Ken Paxton parroted claims by the Health Secretary which have been strongly refuted by medical professionals

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‘I’ve never heard anything like that before,’ said air traffic control

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While the government does not keep a record of the number of British nationals overseas, around 5,000 British nationals are thought to be on the island

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As the temperatures start to drop, some of us are feeling the chill more than others – here’s why

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Zachary Porthen will make his international bow at Wembley with Kolbe deployed at full-back

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Donald Trump appeared to wander off while being given a tour by new Japanese prime minister Sanae Takaichi.

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A total of 9,462,185 Penalty Charge Notices were given out last year, new data from London Councils has revealed

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Sean Bean has revealed that Daniel Day-Lewis invited him over to spend time at his house before they began filming Anemone.

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I spent weeks testing a range of heated clothes airers in a real household setting

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From incredible storylines and expansive worlds to family-friendly fun, I share my pick of the best PS5 games

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The 25-year-old has been linked with top English club Saracens

Experts at Naples' Tesoro di San Gennaro use technology to keep gems secure

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Monday’s incident at PPG Paints Arena marks the third fall at a major Pittsburgh sports venue this year

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We put a range of brollies to the test in drizzle, heavy rain and wind over several weeks

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Court records show that at least two of the men are employees of the restaurant Yucatan

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Scottish musician accused Shakira of ‘stripping off’ for attention in her 2010 music video

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I whipped up all manner of meals to bring you my pick of the top-performing pans

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The 18-year-old has been handed a sponsor exemption

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Three roads will remain closed until 2026

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Millions of Americans have to fight feelings of lethargy and sadness that come with the colder seasons

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Kelce is the fourth tight end in NFL history to catch 100 touchdown passes

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The 18-year-old Russian singer was arrested after her street performance of an anti-Putin song went viral

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President’s attorneys resurrect legal arguments to overturn jury’s verdict in a case that was ‘fatally marred’

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The Reds turn their attention to the Carabao Cup after a run of four straight defeats in the Premier League

The Blues will be able to call on Liam Delap on Wednesday after two months out, although other injury issues persist

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The estate is fortified by high fences, with access restricted to security-controlled entry points

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Compare over 60 licensed and regulated betting sites in the UK and read our reviews of the best online bookmakers for October 2025

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Back-up Inter goalkeeper Martinez was on his way to training when an 81-year-old man in an electric wheelchair was struck and killed, with reports stating the elderly gentleman had a medical episode just prior to impact

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Prunella Scales played Sybil, the long-suffering wife of bumbling hotelier Basil Fawlty

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More than 100 investigators are racing to solve the daring heist at the Louvre Museum

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A new clinical trial has found that adding repeated intravenous ketamine infusions to standard care for hospitalized patients with serious depression did not provide a significant additional benefit. The study, which compared ketamine to a psychoactive placebo, suggests that previous estimates of the drug’s effectiveness might have been influenced by patient and clinician expectations. These findings were published in the journal JAMA Psychiatry.
Ketamine, originally developed as an anesthetic, has gained attention over the past two decades for its ability to produce rapid antidepressant effects in individuals who have not responded to conventional treatments. Unlike standard antidepressants that can take weeks to work, a single infusion of ketamine can sometimes lift mood within hours. A significant drawback, however, is that these benefits are often short-lived, typically fading within a week.
This has led to the widespread practice of administering a series of infusions to sustain the positive effects. A central challenge in studying ketamine is its distinct psychological effects, such as feelings of dissociation or detachment from reality. When compared to an inactive placebo like a saline solution, it is very easy for participants and researchers to know who received the active drug, potentially creating strong expectancy effects that can inflate the perceived benefits.
To address this, the researchers designed their study to use an “active” placebo, a drug called midazolam, which is a sedative that produces noticeable effects of its own, making it a more rigorous comparison.
“Ketamine has attracted a lot of interest as a rapidly-acting antidepressant but it has short-lived effects. Therefore, its usefulness is quite limited. Despite this major limitation, ketamine is increasingly being adopted as an off-label treatment for depression, especially in the USA,” said study author Declan McLoughlin, a professor at Trinity College Dublin.
“We hypothesized that repeated ketamine infusions may have more sustained benefit. So far this has been evaluated in only a small number of trials. Another problem is that few ketamine trials have used an adequate control condition to mask the obvious dissociative effects of ketamine, e.g. altered consciousness and perceptions of oneself and one’s environment.”
“To try address some of these issues, we conducted an independent investigator-led randomized trial (KARMA-Dep 2) to evaluate antidepressant efficacy, safety, cost-effectiveness, and quality of life during and after serial ketamine infusions when compared to a psychoactive comparison drug midazolam. Trial participants were randomized to receive up to eight infusions of either ketamine or midazolam, given over four weeks, in addition to all other aspects of usual inpatient care.”
The trial, conducted at an academic hospital in Dublin, Ireland, aimed to see if adding twice-weekly ketamine infusions to the usual comprehensive care provided to inpatients could improve depression outcomes. Researchers enrolled adults who had been voluntarily admitted to the hospital for moderate to severe depression. These participants were already receiving a range of treatments, including medication, various forms of therapy, and psychoeducation programs.
In this randomized, double-blind study, 65 participants were assigned to one of two groups. One group received intravenous ketamine infusions twice a week for up to four weeks, while the other group received intravenous midazolam on the same schedule. The doses were calculated based on body weight. The double-blind design meant that neither the patients, the clinicians rating their symptoms, nor the main investigators knew who was receiving which substance. Only the anesthesiologist administering the infusion knew the assignment, ensuring patient safety without influencing the results.
The primary measure of success was the change in participants’ depression scores, assessed using a standard clinical tool called the Montgomery-Åsberg Depression Rating Scale. This assessment was conducted at the beginning of the study and again 24 hours after the final infusion. The researchers also tracked other outcomes, such as self-reported symptoms, rates of response and remission, cognitive function, side effects, and overall quality of life.
After analyzing the data from 62 participants who completed the treatment phase, the study found no statistically significant difference in the main outcome between the two groups. Although patients in both groups showed improvement in their depressive symptoms during their hospital stay, the group receiving ketamine did not fare significantly better than the group receiving midazolam. The average reduction in depression scores was only slightly larger in the ketamine group, a difference that was small and could have been due to chance.
Similarly, there were no significant advantages for ketamine on secondary measures, including self-reported depression symptoms, cognitive performance, or long-term quality of life. While the rate of remission from depression was slightly higher in the ketamine group (about 44 percent) compared to the midazolam group (30 percent), this difference was not statistically robust. The treatments were found to be generally safe, though ketamine produced more dissociative experiences during the infusion, while midazolam produced more sedation.
“We found no significant difference between the two groups on our primary outcome measure (i.e. depression severity assessed with the commonly used Montgomery-Åsberg Depression Rating Scale (MADRS)),” McLoughlin told PsyPost. “Nor did we find any difference between the two groups on any other secondary outcome or cost-effectiveness measure. Under rigorous clinical trial conditions, adjunctive ketamine provided no additional benefit to routine inpatient care during the initial treatment phase or the six-month follow-up period.”
A key finding emerged when the researchers checked how well the “blinding” had worked. They discovered that it was not very successful. From the very first infusion, the clinicians rating patient symptoms were able to guess with high accuracy who was receiving ketamine.
Patients in the ketamine group also became quite accurate at guessing their treatment over time. This functional unblinding complicates the interpretation of the results, as the small, nonsignificant trend favoring ketamine could be explained by the psychological effect of knowing one is receiving a treatment with a powerful reputation.
“Our initial hypothesis was that repeated ketamine infusions for people hospitalised with depression would improve mood outcomes,” McLoughlin said. “However, contrary to our hypothesis, we found this not to be the case. We suspect that functional unblinding (due to its obvious dissociative effects) has amplified the placebo effects of ketamine in previous trials. This is a major, often unacknowledged, problem with many recent trials in psychiatry evaluating ketamine, psychedelic, and brain stimulation therapies. Our trial highlights the importance of reporting the success, or lack thereof, of blinding in clinical trials.”
The study’s authors acknowledged some limitations. The research was unable to recruit its planned number of participants, partly due to logistical challenges created by the COVID-19 pandemic. This smaller sample size reduced the study’s statistical power, making it harder to detect a real, but modest, difference between the treatments if one existed. The primary limitation, however, remains the challenge of blinding.
The results from this trial suggest that when tested under more rigorous conditions, the antidepressant benefit of repeated ketamine infusions may be smaller than suggested by earlier studies that used inactive placebos. The researchers propose that expectations for both patients and clinicians may play a substantial role in ketamine’s perceived effects. This highlights the need to recalibrate expectations for ketamine in clinical practice and for more robustly designed trials in psychiatry.
Looking forward, the researchers emphasize the importance of reporting negative or null trial results to provide a balanced view of a treatment’s capabilities. They also expressed concern about a separate in the field: the promotion of ketamine as an equally effective alternative to electroconvulsive therapy, or ECT.
“Scrutiny of the scientific literature shows that this includes methodologically flawed trials and invalid meta-analyses,” McLoughlin said. “We discuss this in some detail in a Comment piece just published in Lancet Psychiatry. Unfortunately, such errors have been accepted as scientific evidence and are already creeping into international clinical guidelines. There is a thus a real risk of patients and clinicians being steered towards a less effective treatment, particularly for patients with severe, sometimes life-threatening, depression.”
The study, “Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression: The KARMA-Dep 2 Randomized Clinical Trial,” was authored by Ana Jelovac, Cathal McCaffrey, Masashi Terao, Enda Shanahan, Emma Whooley, Kelly McDonagh, Sarah McDonogh, Orlaith Loughran, Ellie Shackleton, Anna Igoe, Sarah Thompson, Enas Mohamed, Duyen Nguyen, Ciaran O’Neill, Cathal Walsh, and Declan M. McLoughlin.

A new study suggests that higher levels of psychopathic traits are associated with lower relationship satisfaction in romantic couples. The research indicates that a person’s perception of their partner’s traits is a particularly strong predictor of their own discontent within the relationship. The findings were published in the Journal of Couple & Relationship Therapy.
The research team was motivated by the established connection between personality and the quality of romantic relationships. While traits like agreeableness and conscientiousness are known to support relationship satisfaction, maladaptive traits, such as those associated with psychopathy, are understood to be detrimental. Psychopathy is not a single trait but a combination of characteristics, including interpersonal manipulation, a callous lack of empathy, an erratic lifestyle, and antisocial tendencies.
Previous studies have shown that individuals with more pronounced psychopathic traits tend to prefer short-term relationships, are more likely to be unfaithful, and may engage in controlling or destructive behaviors. Yet, much of this research did not simultaneously account for the perspectives of both partners in a relationship. The researchers aimed to provide a more nuanced understanding by examining how both a person’s own traits and their partner’s traits, as viewed by themselves and by their partner, collectively influence relationship satisfaction.
To investigate these dynamics, the researchers recruited a sample of 85 heterosexual couples from the Netherlands. The participants were predominantly young adults, many of whom were students. Each member of the couple independently completed a series of online questionnaires. The surveys were designed to measure their own psychopathic traits, their perception of their partner’s psychopathic traits, and their overall satisfaction with their relationship.
For measuring psychopathic traits, the study used a well-established questionnaire that assesses three primary facets: Interpersonal Manipulation (e.g., being charming but deceptive), Callous Affect (e.g., lacking guilt or empathy), and Erratic Lifestyle (e.g., impulsivity and irresponsibility). A fourth facet, Antisocial Tendencies, was excluded from the final analysis due to statistical unreliability within this specific sample. Participants completed one version of this questionnaire about themselves and a modified version about their romantic partner.
The researchers used a specialized statistical technique called the Actor-Partner Interdependence Model to analyze the data. This method is uniquely suited for studying couples because it can distinguish between two different kinds of influence. “Actor effects” refer to the association between an individual’s own characteristics and their own outcomes. For example, it can measure how your self-rated manipulativeness relates to your own relationship satisfaction. “Partner effects” describe the association between an individual’s characteristics and their partner’s outcomes, such as how your self-rated manipulativeness relates to your partner’s satisfaction.
Before conducting the main analysis, the researchers examined how partners’ ratings related to one another. They found very little “actual similarity,” meaning that a man’s level of psychopathic traits was not significantly related to his female partner’s level. However, they did find moderate “perceptual accuracy,” which means that how a person rated their partner was generally in line with how that partner rated themselves. There was also strong “perceptual similarity,” indicating that people tended to rate their partners in a way that was similar to how they rated themselves.
One notable preliminary finding was that both men and women tended to rate their partners as having lower levels of psychopathic traits than their partners reported for themselves. This could suggest a positive bias, where individuals maintain a more charitable view of their partner, or it may indicate that certain maladaptive traits are not easily observable to others in a relationship.
The central findings of the study emerged from the Actor-Partner Interdependence Model. The most consistent result was a negative actor effect related to partner perception. When an individual rated their partner higher on psychopathic traits, that same individual reported lower satisfaction with the relationship. This connection was present for both men and women and held true across the total psychopathy score and its specific facets.
The study also identified other significant associations. For both men and women, rating oneself higher on Interpersonal Manipulation was linked to lower satisfaction in one’s own relationship. This suggests that a manipulative style may be unfulfilling even for the person exhibiting it.
A partner effect was observed for the trait of Callous Affect. When a person was perceived by their partner as being more callous, unemotional, and lacking in empathy, that partner reported lower relationship satisfaction. This highlights the direct interpersonal damage that a lack of emotional connection can inflict on a relationship.
In an unexpected turn, the analysis revealed one positive association. When women rated themselves as higher in Callous Affect, their male partners reported slightly higher levels of relationship satisfaction. The researchers propose that this could be related to gender stereotypes, where traits that might be labeled as callous in a clinical sense could be interpreted differently, perhaps as toughness or independence, in women by their male partners.
The study has some limitations that the authors acknowledge. The sample consisted of young, primarily student-based, heterosexual couples in relatively short-term relationships, which may not represent the dynamics in older, married, or more diverse couples. Because the study captured data at a single point in time, it cannot establish causality; it shows an association, not that psychopathic traits cause dissatisfaction. The sample size also meant the study was better equipped to detect medium-to-large effects, and smaller but still meaningful associations might have been missed.
Future research could build on these findings by studying larger and more diverse populations over a longer period. Following couples over time would help clarify how these personality dynamics affect relationship quality and stability as the relationship matures. A longitudinal approach could also determine if these traits predict relationship dissolution.
The study, “Psychopathic Traits and Relationship Satisfaction in Intimate Partners: A Dyadic Approach,” was authored by Frederica M. Martijn, Liam Cahill, Mieke Decuyper, and Katarzyna (Kasia) Uzieblo.



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